Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association...

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Bibliographic Details
Published in:Case reports in oncology 2013-03, Vol.6 (1), p.163-168
Main Authors: Mrzljak, Anna, Košuta, Iva, Škrtić, Anita, Kardum-Skelin, Ika, Vrhovac, Radovan
Format: Article
Language:English
Subjects:
Acute leukemia
Cholangiocellular carcinoma
Gastrointestinal stromal tumor
Liver transplantation
Published: March 2013
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Summary:The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association of GISTs and other neoplasms in a transplant population where long-term immunosuppression carries the additional burden of de novo malignancy. We present a case of posttransplant metachronous GIST and acute biphenotypic leukemia in a patient transplanted for intrahepatic cholangiocellular carcinoma, emphasizing the possible link between mechanisms of carcinogenesis and influence of other factors upon their development.
ISSN:1662-6575
1662-6575
DOI:10.1159/000348817