Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication

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Published in:Antimicrobial Agents and Chemotherapy 2012-12, Vol.56 (12), p.6186-6191
Main Authors: SCHINAZI, Raymond F, BASSIT, Leda, CLAYTON, Marcia M, SUN, Bill, KOHLER, James J, OBIKHOD, Aleksandr, ARZUMANYAN, Alla, FEITELSON, Mark A
Format: Article
Language:English
Subjects:
Adenine
Adenine - analogs & derivatives
Adenine - pharmacology
Adenine - therapeutic use
Adenine - toxicity
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Antiviral Agents - toxicity
Biological and medical sciences
Cell Line
Deoxycytidine
Deoxycytidine - analogs & derivatives
Deoxycytidine - pharmacology
Deoxycytidine - therapeutic use
Deoxycytidine - toxicity
Drug Combinations
Drug Interactions
Emtricitabine
Hepatitis B
Hepatitis B - drug therapy
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - drug effects
Human viral diseases
Infectious diseases
Medical sciences
Mice
Mice, Nude
Organophosphonates
Organophosphonates - pharmacology
Organophosphonates - therapeutic use
Organophosphonates - toxicity
Pharmacology. Drug treatments
Phosphorylation
Polymerase Chain Reaction
Reverse Transcriptase Inhibitors
Reverse Transcriptase Inhibitors - pharmacology
Reverse Transcriptase Inhibitors - therapeutic use
Reverse Transcriptase Inhibitors - toxicity
Tenofovir
Viral diseases
Viral hepatitis
Viremia - drug therapy
Viremia - virology
Virus Replication
Virus Replication - drug effects
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01483-12