Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings

Osteochondroma is a cartilage capped benign tumor developing mainly at the juxta-epiphyseal region of long bones. The rate of malignant transformation, mainly into chondrosarcoma, is estimated to be less than 1-3%. Transformation into osteosarcoma is very rare and has been reported only thirteen tim...

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Bibliographic Details
Published in:Genetics and molecular research 2012-01, Vol.11 (1), p.448
Main Authors: Engel, E E, Nogueira-Barbosa, M H, Brassesco, M S, Silva, G E B, Valera, E T, Peria, F M, Motta, T C, Tone, L G
Format: Article
Language:English
Subjects:
Adult
Bone Neoplasms - genetics
Bone Neoplasms - pathology
Bone Neoplasms - surgery
Chromosome Banding - methods
Humans
Karyotype
Male
Osteochondroma - genetics
Osteochondroma - pathology
Osteosarcoma - genetics
Osteosarcoma - pathology
Osteosarcoma - secondary
Osteosarcoma - surgery
Tibia - pathology
Young Adult
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Summary:Osteochondroma is a cartilage capped benign tumor developing mainly at the juxta-epiphyseal region of long bones. The rate of malignant transformation, mainly into chondrosarcoma, is estimated to be less than 1-3%. Transformation into osteosarcoma is very rare and has been reported only thirteen times. There is little information on treatment and outcome. We report the case of a secondary osteosarcoma arising in the left tibia of a 23-year-old male, 10 years after the initial diagnosis of osteochondroma and after two partial resections. Malignant transformation occurred at the stalk and not at the cartilage cap, as would normally be expected. Chromosome banding analysis revealed the karyotype: 46,XY, t(3;13)(q21;q34) [2]/46,XY [18]. Records from additional cases will help determine the parameters that define these rare secondary bone lesions.
ISSN:1676-5680
DOI:10.4238/2012.March.1.1