Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands. Silver co...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2012-04, Vol.41 (13), p.372-3725
Main Authors: Monteiro, Diana C. F, Phillips, Roger M, Crossley, Benjamin D, Fielden, Jake, Willans, Charlotte E
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Bearing
Carbenes
Cationic
Cell Line, Tumor
Heterocyclic Compounds - chemistry
Humans
Libraries
Ligands
Methane - analogs & derivatives
Methane - chemistry
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Silver
Silver - chemistry
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Summary:A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands. Silver complexes bearing chelating N-heterocyclic carbene ligands exhibit enhanced cytotoxicity over monodentate ligands against the adenocarcinomas MCF7 and DLD1.
ISSN:1477-9226
1477-9234
DOI:10.1039/c2dt12399a