Markers of oxidative stress are increased in exhaled breath condensates of children with atopic dermatitis

Summary Background  Airway inflammation may be present in subjects affected by atopic dermatitis (AD) but still without asthma symptoms. Exhaled breath condensate (EBC) reflects the composition of bronchoalveolar extracellular lining fluid that contains a large number of mediators of airway inflamma...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2012-04, Vol.166 (4), p.839-843
Main Authors: Peroni, D.G., Bodini, A., Corradi, M., Coghi, A., Boner, A.L., Piacentini, G.L.
Format: Article
Language:English
Subjects:
Airway Resistance - physiology
Aldehydes - metabolism
Allergic diseases
Biological and medical sciences
Biomarkers - metabolism
Breath Tests
Case-Control Studies
Child
Child, Preschool
Dermatitis, Atopic - metabolism
Dermatitis, Atopic - physiopathology
Dermatology
Dinoprost - analogs & derivatives
Dinoprost - metabolism
Female
General aspects
Humans
Hydrogen-Ion Concentration
Immunopathology
Leukotriene B4 - metabolism
Male
Malondialdehyde - metabolism
Medical sciences
Oxidative Stress - physiology
Skin allergic diseases. Stinging insect allergies
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Summary:Summary Background  Airway inflammation may be present in subjects affected by atopic dermatitis (AD) but still without asthma symptoms. Exhaled breath condensate (EBC) reflects the composition of bronchoalveolar extracellular lining fluid that contains a large number of mediators of airway inflammation and oxidative damage. Objectives  We assessed inflammatory markers in the EBC of patients with AD. Fifty‐six children (34 girls and 22 boys) were enrolled: 33 affected by AD and 23 healthy controls. Methods  EBC was collected using a condenser device. We measured EBC pH and concentrations of leukotriene B4 (LTB4), 8‐isoprostane, H2O2, malondialdehyde and 4‐hydroxynoneal. Respiratory resistance was also evaluated. Results  EBC pH in patients with AD was significantly lower than in healthy children, median (range) being 8·02 (7·94–8·12) in AD vs. 8·11 (8·05–8·16) (P = 0·02). The values of exhaled 8‐isoprostane and LTB4 were significantly increased in subjects with AD compared with normal controls (P 
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.2011.10771.x