Acinetobacter: A potential reservoir and dispenser for β-lactamases

Innate resistance and remarkable ability to acquire additional resistance determinants underline the clinical importance of Acinetobacter. Over 210 β-lactamases belonging to 16 families have been identified in the genus, mostly in clinical isolates of A. baumannii. In this review, we update the curr...

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Bibliographic Details
Published in:Critical reviews in microbiology 2012-02, Vol.38 (1), p.30-51
Main Authors: Zhao, Wei-Hua, Hu, Zhi-Qing
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter - classification
Acinetobacter - enzymology
Acinetobacter - genetics
Acinetobacter - isolation & purification
Acinetobacter Infections - microbiology
Acinetobacter-derived cephalosporinase (ADC)
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
beta-Lactamases - genetics
beta-Lactamases - metabolism
Biological and medical sciences
carbapenem-hydrolysing class D β-lactamase (CHDL)
Fundamental and applied biological sciences. Psychology
Humans
insertion sequence (IS)
integron
Integrons
Microbiology
Miscellaneous
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Summary:Innate resistance and remarkable ability to acquire additional resistance determinants underline the clinical importance of Acinetobacter. Over 210 β-lactamases belonging to 16 families have been identified in the genus, mostly in clinical isolates of A. baumannii. In this review, we update the current taxonomy of the genus Acinetobacter and summarize the β-lactamases detected in Acinetobacter spp. with an emphasis on Acinetobacter-derived cephalosporinases (ADCs) and carbapenem-hydrolysing class D β-lactamases (CHDLs). We also discuss the roles of integrons and insertion sequence (IS) elements in the expression and dissemination of such resistance determinants.
ISSN:1040-841X
1549-7828
DOI:10.3109/1040841X.2011.621064