Benzo[a]pyrene Exposure Increases Toxic Biomarkers and Morphological Disorders in Mouse Cervix

:  Benzo[a]pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons exerting cytotoxicity and genotoxicity in the human liver, lung, stomach and skin. However, the toxic effect of BaP on cervical tissue remains unclear. This study was carried out to investigate the toxic effects...

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Bibliographic Details
Published in:Basic & clinical pharmacology & toxicology 2011-11, Vol.109 (5), p.398-406
Main Authors: Gao, Meili, Li, Yongfei, Sun, Ying, Shah, Walayat, Yang, Shuiyun, Wang, Yili, Long, Jiangang
Format: Article
Language:English
Subjects:
Animals
Aspartate Aminotransferases - metabolism
Benzo(a)pyrene - toxicity
Biological and medical sciences
Biomarkers
Body Weight - drug effects
Cervix Uteri - drug effects
Cervix Uteri - pathology
Creatine Kinase - metabolism
Cytochrome P-450 CYP1A1 - metabolism
Female
Glutathione Transferase - metabolism
Injections, Intraperitoneal
Interleukin-6 - analysis
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Malondialdehyde - analysis
Medical sciences
Mice
Mice, Inbred ICR
Pharmacology. Drug treatments
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Summary::  Benzo[a]pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons exerting cytotoxicity and genotoxicity in the human liver, lung, stomach and skin. However, the toxic effect of BaP on cervical tissue remains unclear. This study was carried out to investigate the toxic effects of BaP on the cervix of ICR mice. Female mice were treated with BaP by intraperitoneal injection and oral gavage at a dose of 2.5, 5 and 10 mg/kg body‐weight, twice a week for 14 weeks. BaP treatment caused a significant increase in the levels of MDA and IL‐6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione‐S‐transferase in the cervix and liver. The relative cervix weight was markedly reduced in the intraperitoneal BaP injection groups, whereas only a slight reduction was observed in the oral gavage groups. The increase in weight decreased with increasing BaP dose. Moreover, BaP treatment induced significant pathomorphological changes in the cervical tissue and increased the mortality of the mice. Taken together, these results suggest that BaP causes a certain toxic effect on cervical tissue.
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2011.00755.x