Use of serum circulating CCNB2 in cancer surveillance

Cyclin B2 (CCNB2), a member of the cyclin protein family, has been found to be up-regulated in human cancers. To evaluate the potential use of circulating CCNB2 in serum in cancer surveillance, we examined relative expression levels of serum circulating CCNB2 mRNA in 103 cancer patients, 19 normal c...

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Published in:The International journal of biological markers 2010-10, Vol.25 (4), p.236
Main Authors: Mo, Min-Li, Chen, Zhao, Li, Jie, Li, Hai-Long, Sheng, Qing, Ma, Hui-Yan, Zhang, Fang-Xin, Hua, Ya-Wei, Zhang, Xun, Sun, Da-Qiang, Xu, Mei-Lin, Niu, Run-Gui, Xu, Jun-Pu, Zuo, Hui-Jing, Liu, Min, Zhou, Hai-Meng
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - blood
Case-Control Studies
Cyclin B2 - blood
Cyclin B2 - genetics
Digestive System Neoplasms - diagnosis
Digestive System Neoplasms - pathology
Female
Genital Neoplasms, Female - diagnosis
Genital Neoplasms, Female - pathology
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasms - diagnosis
Neoplasms - pathology
RNA, Messenger - blood
Transcriptional Activation
Urinary Bladder Neoplasms - diagnosis
Urinary Bladder Neoplasms - pathology
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Summary:Cyclin B2 (CCNB2), a member of the cyclin protein family, has been found to be up-regulated in human cancers. To evaluate the potential use of circulating CCNB2 in serum in cancer surveillance, we examined relative expression levels of serum circulating CCNB2 mRNA in 103 cancer patients, 19 normal controls, and 40 benign disease patients using real-time quantitative reverse transcriptase polymerase chain reaction. We found that the relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher (p
ISSN:1724-6008
DOI:10.5301/JBM.2010.6088