Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats

Abstract Background. This study examined the effect of renal sympathetic innervation on adrenergically and angiotensin II (Ang II)-induced renal vasoconstriction in Wistar-Kyoto (WKY) rats. Methods. Forty-eight WKY rats were treated with either losartan (10 mg/kg/day p.o.) or carvedilol (5 mg/kg/day...

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Published in:Upsala journal of medical sciences 2011-03, Vol.116 (1), p.18-25
Main Authors: Abdulla, Mohammed H., Sattar, Munavvar A., Abdullah, Nor A., Khan, Abdul Hye, Anand Swarup, Kolla R. L., Rathore, Hassaan A., Kazi, Raisa N., Basri, Fathihah, Johns, Edward J.
Format: Article
Language:English
Subjects:
Adrenergic alpha-1 Receptor Agonists - pharmacology
Adrenoceptors
Angiotensin II - pharmacology
Animals
Blood Pressure - drug effects
carvedilol
Kidney - innervation
losartan
Male
Methoxamine - pharmacology
Norepinephrine - pharmacology
Original
Rats
Rats, Inbred WKY
Receptor, Angiotensin, Type 1 - physiology
Receptors, Adrenergic, alpha-1 - physiology
Renal Circulation - drug effects
renal haemodynamics
Rodents
Sympathetic Nervous System - physiology
Vasoconstriction - drug effects
Wistar-Kyoto rats
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Summary:Abstract Background. This study examined the effect of renal sympathetic innervation on adrenergically and angiotensin II (Ang II)-induced renal vasoconstriction in Wistar-Kyoto (WKY) rats. Methods. Forty-eight WKY rats were treated with either losartan (10 mg/kg/day p.o.) or carvedilol (5 mg/kg/day p.o.) or a combination of them (10 mg/kg/day + 5 mg/kg/day p.o.) for 7 days. On day 8, the rats were anaesthetized, and renal vasoconstrictor experiments were carried out. A group of rats was subjected to acute unilateral renal denervation during the acute study. Changes in the renal vasoconstrictor responses were determined in terms of reductions in renal blood flow caused by Ang II, noradrenaline (NA), and methoxamine (ME). Results. In normal animals, losartan decreased (P < 0.05) the renal vasoconstrictor response to Ang II but not to NA or ME. Carvedilol treatment, however, blunted (P < 0.05) the renal vasoconstrictor responses to Ang II and adrenergic agonists. Combination of losartan and carvedilol blunted (P < 0.05) the renal vasoconstrictor response to Ang II but augmented the responses to NA and ME (all P < 0.05). Interestingly, when denervated rats were treated with the same combination, there was a reduction (P < 0.05) in the renal vasoconstrictor responses to Ang II and adrenergic agonists. Conclusions. Data suggest that the renal sympathetic nerve contributes to adrenergic agonist-mediated renal vasoconstrictions in normal rats. The data further indicate an interactive relationship between renin-angiotensin and sympathetic nervous systems in modulating adrenergically and Ang II-induced renal vasoconstriction in WKY rats.
ISSN:0300-9734
2000-1967
DOI:10.3109/03009734.2010.526723