Light at night increases body mass by shifting the time of food intake

The global increase in the prevalence of obesity and metabolic disorders coincides with the increase of exposure to light at night (LAN) and shift work. Circadian regulation of energy homeostasis is controlled by an endogenous biological clock that is synchronized by light information. To promote op...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS 2010-10, Vol.107 (43), p.18664-18669
Main Authors:	Fonken, Laura K., Workman, Joanna L., Walton, James C., Weil, Zachary M., Morris, John S., Haim, Abraham, Nelson, Randy J., Denlinger, David L.
Format:	Article
Language:	eng
Subjects:	Animals Biological clocks Biological Sciences Body Mass Index Circadian Rhythm Disease Models, Animal Eating - physiology Eating - psychology Eating - radiation effects Energy Intake Feeding Behavior - physiology Feeding Behavior - psychology Feeding Behavior - radiation effects Food Food access Food consumption Food intake Glucocorticoids Glucose Tolerance Test Homeostasis Humans Light Locomotion Male Metabolic Syndrome - etiology Metabolism Mice Motor Activity Obesity Obesity - etiology Obesity - pathology Obesity - physiopathology Obesity - psychology Photoperiod Rodents Shift work
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Summary:	The global increase in the prevalence of obesity and metabolic disorders coincides with the increase of exposure to light at night (LAN) and shift work. Circadian regulation of energy homeostasis is controlled by an endogenous biological clock that is synchronized by light information. To promote optimal adaptive functioning, the circadian clock prepares individuals for predictable events such as food availability and sleep, and disruption of clock function causes circadian and metabolic disturbances. To determine whether a causal relationship exists between nighttime light exposure and obesity, we examined the effects of LAN on body mass in male mice. Mice housed in either bright (LL) or dim (DM) LAN have significantly increased body mass and reduced glucose tolerance compared with mice in a standard (LD) light/dark cycle, despite equivalent levels of caloric intake and total daily activity output. Furthermore, the timing of food consumption by DM and LL mice differs from that in LD mice. Nocturnal rodents typically eat substantially more food at night; however, DM mice consume 55.5% of their food during the light phase, as compared with 36.5% in LD mice. Restricting food consumption to the active phase in DM mice prevents body mass gain. These results suggest that low levels of light at night disrupt the timing of food intake and other metabolic signals, leading to excess weight gain. These data are relevant to the coincidence between increasing use of light at night and obesity in humans.
ISSN:	0027-8424 1091-6490