Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57 degrees N and 51 degrees N: a longitudinal study

The UK has insufficient intensity of sunlight at wavelengths 290-315 nm to enable cutaneous synthesis of vitamin D from October to April. There are regional differences in UVB strength throughout the UK but whether this translates to differences in vitamin D status is not known. We have reported sea...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2010-07, Vol.121 (1-2), p.459
Main Authors: Mavroeidi, A, O'Neill, F, Lee, P A, Darling, A L, Fraser, W D, Berry, J L, Lee, W T, Reid, D M, Lanham-New, S A, Macdonald, H M
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Bone and Bones - metabolism
Cohort Studies
Ethnic Groups
European Continental Ancestry Group
Female
Humans
Immunoenzyme Techniques
Longitudinal Studies
Middle Aged
Postmenopause
Seasons
United Kingdom
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:The UK has insufficient intensity of sunlight at wavelengths 290-315 nm to enable cutaneous synthesis of vitamin D from October to April. There are regional differences in UVB strength throughout the UK but whether this translates to differences in vitamin D status is not known. We have reported seasonal variations in a cross-sectional study of over 3000 Scottish women in Aberdeen. The aim of this longitudinal study was to compare the seasonal variation of serum 25-hydroxyvitamin D [25(OH)D] in postmenopausal women residing in Aberdeen (57 degrees N) and Surrey (51 degrees N). Women attended 3-monthly visits over 12 months, starting summer 2006. In Aberdeen, 338 Caucasian women (mean age+/-SD, 61.7+/-1.5 years); and at Surrey, 138 Caucasian women (61.4+/-4.5 years) and 35 Asian women (59.9+/-6.4 years) had serum 25(OH)D measured by IDS enzyme immunoassay. In winter/spring none of the Caucasian women living in Surrey had 25(OH)D
ISSN:1879-1220
DOI:10.1016/j.jsbmb.2010.03.038