Aortic and venous valve for percutaneous insertion

Summary The purpose of this paper is to present in vitro and in vivo experimental evaluation of a new, artificial, bicuspid, aortic and venous valve. Valves were constructed from square stents with barbs covered by porcine small intestine submucosa (SIS). A valve 15 mm in diameter was tested in a fl...

Full description

Saved in:
Bibliographic Details
Published in:Minimally invasive therapy and allied technologies 2000, Vol.9 (3-4), p.287-292
Main Authors: Pavcnik, D., Uchida, B. T., Timmermans, H., Corless, C. L., Keller, F. S., Rösen, J.
Format: Article
Language:English
Subjects:
Animals
aortic valve
Aortic Valve - pathology
Aortic Valve - surgery
Biocompatible Materials
biomaterial
Catheterization
Dogs
experimental
interventional procedures
Pilot Projects
Stents
stents and prostheses
Stroke Volume
Swine
Vena Cava, Inferior
venous valve
Venous Valves - pathology
Venous Valves - surgery
Ventricular Function, Left
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The purpose of this paper is to present in vitro and in vivo experimental evaluation of a new, artificial, bicuspid, aortic and venous valve. Valves were constructed from square stents with barbs covered by porcine small intestine submucosa (SIS). A valve 15 mm in diameter was tested in a flow model (2.5 l min) with pressure measurement. A 100-ml rubber bag attached to a side arm of the flow model simulated heart ejection fraction. In acute (n=6) and short-term (n=3) experiments conducted in four swine and four dogs, valves ranging from 16 - 28mm in diameter were placed into the ascending aorta through 10 F sheaths; three were placed subcoronary and six in a supracoronary position. Function and stability of the valves were studied with pressure measurements and aortograms. Three short-term animals were sacrificed for gross and histologic evaluation at one, two and four weeks respectively. In an acute experiment, venous valves with four barbs were placed into the IVC through an 8 F guiding catheter in three dogs. For longer-term testing, valves were placed into the IVCs and iliac veins of three young swine. The animals were followed up after two weeks with venograms, then were sacrificed for gross and histologic evaluation.
ISSN:1364-5706
1365-2931
DOI:10.1080/13645700009169659