Gold nanotags for combined multi-colored Raman spectroscopy and x-ray computed tomography

Multi-color gold-nanoparticle-based tags (nanotags) are synthesized for combined surface-enhanced Raman spectroscopy (SERS) and x-ray computed tomography (CT). The nanotags are synthesized with quasi-spherical gold nanoparticles encoded with a reporter dye (color), each with a unique Raman spectrum....

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Bibliographic Details
Published in:Nanotechnology 2010-01, Vol.21 (3), p.035101-035101
Main Authors: Xiao, Ming, Nyagilo, James, Arora, Veera, Kulkarni, Padmakar, Xu, Dongsheng, Sun, Xiankai, Davé, Digant P
Format: Article
Language:English
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Summary:Multi-color gold-nanoparticle-based tags (nanotags) are synthesized for combined surface-enhanced Raman spectroscopy (SERS) and x-ray computed tomography (CT). The nanotags are synthesized with quasi-spherical gold nanoparticles encoded with a reporter dye (color), each with a unique Raman spectrum. A library of nanotags with six different colors were synthesized for a range of gold nanoparticle sizes and an optimum size has been established to yield the largest SERS intensity and x-ray attenuation that is higher than the iodinated CT contrast agents used in clinics. Proof-of-principle in vivo imaging results with nanotags are presented that, for the first time, demonstrates the combined in vivo dual modality imaging capability of SERS and CT with a single nanoparticle probe.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/21/3/035101