Lymphocyte subsets in schizophrenic disorders: relationship with clinical, neuromorphological and treatment variables

Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagno...

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Bibliographic Details
Published in:Schizophrenia research 1990-07, Vol.3 (4), p.269-275
Main Authors: Masserini, Cinzia, Vita, Antonio, Basile, Roberto, Morselli, Raffaele, Boato, Paolo, Peruzzi, Cinzia, Pugnetti, Luigi, Ferrante, Pasquale, Cazzullo, Carlo Lorenzo
Format: Article
Language:English
Subjects:
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Atrophy
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Brain - pathology
Female
Humans
Immunoglobubin
Immunoglobulins - analysis
Leukocyte Count - drug effects
Lymphocyte subset
Lymphocyte Subsets - drug effects
Lymphocyte Subsets - immunology
Male
Neuroleptic side effect
Psychotic Disorders - drug therapy
Psychotic Disorders - immunology
Psychotic Disorders - pathology
Psychotic Disorders - psychology
Receptors, Interleukin-2 - drug effects
Receptors, Interleukin-2 - immunology
Schizophrenia - drug therapy
Schizophrenia - immunology
Schizophrenia - pathology
Schizophrenic disorder
Schizophrenic Psychology
T-Lymphocytes, Helper-Inducer - drug effects
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - immunology
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Summary:Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.
ISSN:0920-9964
1573-2509
DOI:10.1016/0920-9964(90)90008-U