Optimizing the CD34 + cell dose for reduced-intensity allogeneic hematopoietic stem cell transplantation

Low CD34 + cell doses increase allograft-related mortality and very high doses increase the risk of graft-versus-host disease. The optimum CD34 + cell dose remains undefined. The effect of the CD34 + cell dose based on ideal weight was analyzed in 130 patients with hematologic malignancies undergoin...

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Bibliographic Details
Published in:Leukemia & lymphoma 2009-01, Vol.50 (9), p.1434-1441
Main Authors: Mehta, Jayesh, Frankfurt, Olga, Altman, Jessica, Evens, Andrew, Tallman, Martin, Gordon, Leo, Williams, Stephanie, Winter, Jane, Krishnamurthy, Jairam, Duffey, Sara, Singh, Veerpal, Meagher, Richard, Grinblatt, David, Kaminer, Lynne, Singhal, Seema
Format: Article
Language:English
Subjects:
Adult
Aged
Allogeneic transplantation
Antigens, CD34 - metabolism
blood
Calibration
CD34 cell dose
Cell Count
Female
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cell Transplantation - standards
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Male
Middle Aged
Retrospective Studies
transplant-related mortality
Transplantation Conditioning - methods
Transplantation, Homologous
Young Adult
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Summary:Low CD34 + cell doses increase allograft-related mortality and very high doses increase the risk of graft-versus-host disease. The optimum CD34 + cell dose remains undefined. The effect of the CD34 + cell dose based on ideal weight was analyzed in 130 patients with hematologic malignancies undergoing reduced-intensity allogeneic blood cell transplantation in the context of factors known to affect the outcome: chemosensitivity, donor age, lactate dehydrogenase (LDH), human leukocyte antigen (HLA) match, performance status, and platelet count. The survival of patients receiving >8 × 106 kg CD34 + cells was not significantly different from those receiving 8) needs further confirmation.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190903085944