Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation

1 Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee; and 2 Department of Technologies for Health, Galeazzi Orthopaedic Institute, University of Milan, Milan; 3 University of Milan, Milan; 4 Internal Medicine "Bol...

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Published in:American journal of physiology. Heart and circulatory physiology 2009-06, Vol.296 (6), p.H1758-H1765
Main Authors: Diedrich, Andre, Porta, Alberto, Barbic, Franca, Brychta, Robert J, Bonizzi, Pietro, Diedrich, Laura, Cerutti, Sergio, Robertson, David, Furlan, Raffaello
Format: Article
Language:English
Subjects:
Blood pressure
Blood Pressure - physiology
Blood Vessels - innervation
Blood Vessels - physiology
Carotid Body - physiology
Electrocardiography
Female
Functional Laterality - physiology
Gene expression
Heart
Heart Rate - physiology
Humans
Male
Middle Aged
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Neurons
Peroneal Nerve - physiology
Pressoreceptors - physiology
Respiratory Mechanics - physiology
Studies
Sympathetic Fibers, Postganglionic - physiology
Sympathetic Nervous System - physiology
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Summary:1 Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee; and 2 Department of Technologies for Health, Galeazzi Orthopaedic Institute, University of Milan, Milan; 3 University of Milan, Milan; 4 Internal Medicine "Bolognini" Hospital, Seriate, Bergamo; and 5 Department of Bioengineering, Politecnico of Milan, Milan, Italy Submitted 30 September 2008 ; accepted in final form 24 March 2009 Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 ± 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to –50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A N (1.36 ± 0.18) and AA N (1.31 ± 0.16) were larger than the left MSNA A N (1.04 ± 0.09) and AA N (1.02 ± 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A N and AA N . In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere. sympathetic control of circulation; muscle sympathetic nerve activity recording; burst amplitude; area; laterality Address for reprint requests and other correspondence: R. Furlan; Unità Sincopi e Disturbi della Postura; Medicina Generale, Ospedale Bolognini; Via Paderno, 24; Seriate (Bg), Italy; Univ. deg
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.01045.2008