Control of cell proliferation pathways by microRNAs

microRNAs (miRNAs) are small non-coding RNAs that regulate a large variety of cellular processes including differentiation, apoptosis and proliferation. Several miRNAs display defective expression patterns in human tumors with the consequent alteration of target oncogene or tumor suppressor genes. M...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Tex.), 2008-10, Vol.7 (20), p.3143-3148
Main Authors:	Bueno, María José, de Castro, Ignacio Pérez, Malumbres, Marcos
Format:	Article
Language:	eng
Subjects:	Animals Binding Biology Bioscience Calcium Cancer Cell Cell Cycle - physiology Cell Proliferation Cycle Humans Landes MicroRNAs - genetics MicroRNAs - metabolism Neoplasms - metabolism Neoplasms - pathology Organogenesis Phosphatidylinositol 3-Kinases - metabolism Proteins rho GTP-Binding Proteins - metabolism Signal Transduction - physiology
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Summary:	microRNAs (miRNAs) are small non-coding RNAs that regulate a large variety of cellular processes including differentiation, apoptosis and proliferation. Several miRNAs display defective expression patterns in human tumors with the consequent alteration of target oncogene or tumor suppressor genes. Many of these miRNAs modulate the major proliferation pathways through direct interaction with critical regulators such as RAS, PI3K/PTEN or ABL, as well as members of the retinoblastoma pathway, Cyclin-CDK complexes or cell cycle inhibitors of the INK4 or Cip/Kip families. A complex interplay between miRNAs and MYC or E2F family members also exists to modulate cell cycle-dependent transcription during normal or tumoral proliferation. The ability of miRNAs to modulate these proliferation pathways may have relevant implications not only in physiological or developmental processes but also in tumor progression or cancer therapy.
ISSN:	1538-4101 1551-4005