New Sulphonamide and Carboxamide Derivatives of Acyclic C-Nucleosides of Triazolo-Thiadiazole and the Thiadiazine Analogues. Synthesis, Anti-HIV, and Antitumor Activities. Part 2

A new series of acyclic C-nucleosides 1′,2′-O-isopropylidene-D-ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upo...

Full description

Saved in:
Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2008-09, Vol.27 (9), p.1034-1044
Main Authors: Al-Masoudi, Najim A., Al-Soud, Yaseen A.
Format: Article
Language:English
Subjects:
acyclic C-nucleosides
anti-HIV activity
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
carboxamides
Cell Line, Tumor
Drug Design
Human immunodeficiency virus
Human immunodeficiency virus 1
Human immunodeficiency virus 2
Humans
Hydrocarbons, Acyclic - chemistry
microwave-assisted synthesis
Microwaves
Molecular Structure
Nucleosides - chemistry
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Sulfonamides - pharmacology
sulphonamides
T-Lymphocytes - drug effects
Thiadiazines - chemistry
Thiadiazoles - chemistry
triazolo-thiadiazoles and -thiadiazines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new series of acyclic C-nucleosides 1′,2′-O-isopropylidene-D-ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upon acid hydrolysis, afforded the free nucleosides 16-18. The new synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound 7 was also screened against a panel of tumor cell lines consisting of CD4 human T-cells.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770802271771