VENO-OCCLUSIVE DISEASE IN A CHILD WITH RHABDOMYOSARCOMA AFTER CONVENTIONAL CHEMOTHERAPY: Report of a Case and Review of the Literature

Although veno-occlusive disease of the liver is a well-known complication of high-dose chemotherapy and bone marrow transplantation, it has rarely been observed in children who receive conventional chemotherapy. Most cases in the literature consists of children with Wilms tumor. It has been very unc...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2007-01, Vol.24 (8), p.615-621
Main Authors: Cecen, Emre, Uysal, Kamer Mutafoglu, Ozguven, Aykan, Gunes, Dilek, Irken, Gulersu, Olgun, Nur
Format: Article
Language:English
Subjects:
ACT-D
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Bone Marrow Transplantation - adverse effects
Child, Preschool
cyclophosphamide
Cyclophosphamide - administration & dosage
Cyclophosphamide - adverse effects
Dactinomycin - administration & dosage
Dactinomycin - adverse effects
Hepatic Veno-Occlusive Disease - chemically induced
Hepatic Veno-Occlusive Disease - pathology
Hepatic Veno-Occlusive Disease - therapy
Humans
Male
Remission Induction
rhabdomyosarcoma
Rhabdomyosarcoma - complications
Rhabdomyosarcoma - drug therapy
VAC chemotherapy
venoocclusive disease
Vincristine - administration & dosage
Vincristine - adverse effects
Wilms Tumor - complications
Wilms Tumor - therapy
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Summary:Although veno-occlusive disease of the liver is a well-known complication of high-dose chemotherapy and bone marrow transplantation, it has rarely been observed in children who receive conventional chemotherapy. Most cases in the literature consists of children with Wilms tumor. It has been very uncommon in rabdomyosarcoma patients until recently, although they commonly receive similar anticancer agents. Here the authors report a 2-year-old boy with rhabdomyosarcoma who developed veno-occlusive disease while receiving VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy regimen according to the IRS-IV protocol. The patient gradually recovered during 2 weeks with supportive treatment only.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010701640390