Gadolinium‐induced nephrogenic systemic fibrosis in a patient with an acute and transient kidney injury

Summary Nephrogenic systemic fibrosis (NSF) describes a characteristic fibrosing disorder which typically presents with indurated plaques on the trunk and extremities of patients with advanced renal disease. We present a case of biopsy‐confirmed NSF in a patient with severe acute kidney injury with...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2008-03, Vol.158 (3), p.607-610
Main Authors: Kalb, R.E., Helm, T.N., Sperry, H., Thakral, C., Abraham, J.L., Kanal, E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Contrast Media - adverse effects
Dermatology
Fibrosis
gadolinium
Gadolinium - adverse effects
Glomerular Filtration Rate
Humans
Kidney - pathology
Kidney Diseases - complications
Kidney Diseases - pathology
kidney injury
Kidneys
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
nephrogenic systemic fibrosis
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Renal failure
Skin - radiation effects
Skin Diseases - chemically induced
transient
Treatment Outcome
Urinary system involvement in other diseases. Miscellaneous
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Summary:Summary Nephrogenic systemic fibrosis (NSF) describes a characteristic fibrosing disorder which typically presents with indurated plaques on the trunk and extremities of patients with advanced renal disease. We present a case of biopsy‐confirmed NSF in a patient with severe acute kidney injury with no prior history of renal disease. A 64‐year‐old man with an acute and severe decrease in glomerular filtration rate underwent magnetic resonance imaging studies with gadolinium contrast (Omniscan™) and subsequently developed NSF. His renal disease had normalized at the time his skin disease developed. Skin biopsies revealed findings of NSF and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy confirmed insoluble gadolinium within lesional tissue.
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.2007.08369.x