Mitochondria in anaesthesia and intensive care

Mitochondria play a key role in energy metabolism within the cell through the oxidative phosphorylation. They are also involved in many cellular processes like apoptosis, calcium signaling or reactive oxygen species production. The objectives of this review are to understand the interactions between...

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Bibliographic Details
Published in:Annales françaises d'anesthésie et de réanimation 2007-04, Vol.26 (4), p.319
Main Authors: Nouette-Gaulain, K, Quinart, A, Letellier, T, Sztark, F
Format: Article
Language:fre
Subjects:
Anesthetics - pharmacology
Apoptosis
Humans
Mitochondria - drug effects
Mitochondria - metabolism
Phosphorylation
Reactive Oxygen Species
Resuscitation
Signal Transduction
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Summary:Mitochondria play a key role in energy metabolism within the cell through the oxidative phosphorylation. They are also involved in many cellular processes like apoptosis, calcium signaling or reactive oxygen species production. The objectives of this review are to understand the interactions between mitochondrial metabolism and anaesthetics or different stress situations observed in ICU and to know the clinical implications. References were obtained from PubMed data bank (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) using the following keywords: mitochondria, anaesthesia, anaesthetics, sepsis, preconditioning, ischaemia, hypoxia. Mitochondria act as a pharmacological target for the anaesthetic agents. The effects can be toxic like in the case of the local anaesthetics-induced myotoxicity. On the other hand, beneficial effects are observed in the anaesthetic-induced myocardial preconditioning. Mitochondrial metabolism could be disturbed in many critical situations (sepsis, chronic hypoxia, ischaemia-reperfusion injury). The study of the underlying mechanisms should allow to propose in the future new specific therapeutics.
ISSN:1769-6623
DOI:10.1016/j.annfar.2007.01.012