Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children

Normal (51)Cr-ethylenediaminetetraacetic acid (EDTA) clearance values as a function of age were published a number of years ago. These values were based on data from children with a normal left to right ratio and a normal appearance on DMSA scintigraphy, despite the presence of an acute renal infect...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2006-12, Vol.33 (12), p.1477
Main Authors: Piepsz, A, Tondeur, M, Ham, H
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Child
Child, Preschool
Chromium Radioisotopes - chemistry
Edetic Acid - chemistry
Edetic Acid - pharmacokinetics
Glomerular Filtration Rate
Humans
Infant
Infant, Newborn
Kidney - diagnostic imaging
Kidney - physiopathology
Metabolic Clearance Rate
Radioisotope Renography
Reference Values
Retrospective Studies
Technetium Tc 99m Dimercaptosuccinic Acid
Urinary Tract Infections - diagnostic imaging
Urinary Tract Infections - metabolism
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Summary:Normal (51)Cr-ethylenediaminetetraacetic acid (EDTA) clearance values as a function of age were published a number of years ago. These values were based on data from children with a normal left to right ratio and a normal appearance on DMSA scintigraphy, despite the presence of an acute renal infection. At that time, the authors were unaware that hyperfiltration is a common phenomenon in patients with acute renal infection and that their normal values could have been significantly overestimated. The present work therefore aimed to re-appraise these normal values. In a first step, in order to verify the previous results, the same type of population was selected, namely patients with present or past urinary tract infection but normal images and a normal left to right ratio on DMSA scintigraphy. In a second step, the selection was based on patients who had had no recent urinary tract infection. In both series, a single blood sample method was used for the evaluation of (51)Cr-EDTA clearance. In the first group of patients, the results obtained were almost identical to those previously published. In the second group of patients, the results were significantly lower: after 2 years of age, the mean GFR value was 104 ml/min/1.73 m(2) (10th and 90th percentiles 81 and 135 ml/min/1.73 m(2), respectively), compared with 117 ml/min/1.73 m(2) in the first group. The data of the second group are probably more representative of the true normal GFR values and can be applied to the entire paediatric population.
ISSN:1619-7089
DOI:10.1007/s00259-006-0179-2