Normalization in quantitative [18F]FDG PET imaging: the 'body surface area' may be a volume

Non-invasive methods for quantifying [(18)F]FDG uptake in tumours often require normalization to either body weight or body surface area (BSA), as a surrogate for [(18)F]FDG distribution volume (DV). Whereas three dimensions are involved in DV and weight (assuming that weight is proportional to volu...

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Bibliographic Details
Published in:Physics in medicine & biology 2006-02, Vol.51 (3), p.N47-N50
Main Authors: Laffon, Eric, Suárez, Kleydis, Berthoumieu, Yannick, Ducassou, Dominique, Marthan, Roger
Format: Article
Language:English
Subjects:
Biophysical Phenomena
Biophysics
Body Surface Area
Body Weight
Fluorodeoxyglucose F18 - chemistry
Fractals
Humans
Models, Theoretical
Positron-Emission Tomography - methods
Radiopharmaceuticals - pharmacology
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Summary:Non-invasive methods for quantifying [(18)F]FDG uptake in tumours often require normalization to either body weight or body surface area (BSA), as a surrogate for [(18)F]FDG distribution volume (DV). Whereas three dimensions are involved in DV and weight (assuming that weight is proportional to volume), only two dimensions are obviously involved in BSA. However, a fractal geometry interpretation, related to an allometric scaling, suggests that the so-called 'body surface area' may stand for DV.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/51/3/N03