An improved synthesis of resveratrol

In this article we report an improved total synthesis of resveratrol, increasing the overall yield from 22 to 71%. The synthesis reported in our previous publication was made up of two fundamental steps: a Wittig reaction and a Heck coupling. Here we studied these steps separately to increase the in...

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Bibliographic Details
Published in:Natural product research 2006-03, Vol.20 (3), p.247-252
Main Authors: Farina, Angela, Ferranti, Carolina, Marra, Carolina
Format: Article
Language:English
Subjects:
Heck reaction
Magnetic Resonance Spectroscopy
Mass Spectrometry
protective group
Resveratrol
stilbene
Stilbenes - chemical synthesis
Wittig reaction
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Summary:In this article we report an improved total synthesis of resveratrol, increasing the overall yield from 22 to 71%. The synthesis reported in our previous publication was made up of two fundamental steps: a Wittig reaction and a Heck coupling. Here we studied these steps separately to increase the individual yields. The yield of the Wittig reaction was increased up to 98%; however, we could not find better reaction conditions for the Heck coupling than those reported in the previous article.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410500059532