EFFECTIVE ARTERIAL ELASTANCE AS INDEX OF ARTERIAL VASCULAR LOAD IN HUMANS

Background. This study tested whether the simple ratio of ventricular end-systolic pressure to stroke volume, known as the effective arterial elastance (E(a)), provides a valid measure of arterial load in humans with normal and aged hypertensive vasculatures. Methods and Results. Ventricular pressur...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1992-08, Vol.86 (2), p.513-521
Main Authors: KELLY, RP, TING, CT, YANG, TM, LIU, CP, MAUGHAN, WL, CHANG, MS, KASS, DA
Format: Article
Language:English
Subjects:
Adult
Aorta - physiology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiac & Cardiovascular Systems
Cardiology. Vascular system
Cardiovascular System & Cardiology
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Humans
Hypertension - physiopathology
Life Sciences & Biomedicine
Male
Medical sciences
Models, Cardiovascular
Models, Theoretical
Myocardial Contraction - physiology
Peripheral Vascular Disease
Pulsatile Flow - physiology
Science & Technology
Space life sciences
Stroke Volume - physiology
Vascular Resistance - physiology
Ventricular Function - physiology
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Summary:Background. This study tested whether the simple ratio of ventricular end-systolic pressure to stroke volume, known as the effective arterial elastance (E(a)), provides a valid measure of arterial load in humans with normal and aged hypertensive vasculatures. Methods and Results. Ventricular pressure-volume and invasive aortic pressure and flow were simultaneously determined in 10 subjects (four young normotensive and six older hypertensive). Measurements were obtained at rest, during mechanically reduced preload, and after pharmacological interventions. Two measures of arterial load were compared: One was derived from aortic input impedance and arterial compliance data using an algebraic expression based on a three-element Windkessel model of the arterial system [E(a)(Z)], and the other was more simply measured as the ratio of ventricular end-systolic pressure to stroke volume [E(a)(PV)]. Although derived from completely different data sources and despite the simplifying assumptions of E(a)(PV), both E(a)(Z) and E(a)(PV) were virtually identical over a broad range of altered conditions: E(a)(PV) = 0.97 . E(a)(Z) +0.17; n=33, r2=0.98, SEE=0.09, p
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.86.2.513