Bromocriptine treatment in a murine parkinson's model: Ultrastructural evaluation after dopaminergic deafferentation

The objective of this article was to identify the effects of bromocriptine on the ultrastructure of the caudate nucleus in rats with a 6-hydroxidopamine (6-OHDA) unilateral lesion of the substantia nigra pars compacta. Eighteen Wistar male rats were stereotactically lesioned with 6-OHDA (n = 12), or...

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Published in:International journal of neuroscience 2005-06, Vol.115 (6), p.851-859
Main Authors: Avila-Costa, Maria Rosa, Coli'n-Barenque, Laura, Montiel-Flores, Enrique, Aley-Medina, Patricia, Valdez, Ana Luisa Gutiérrez, Librado, José Luis Ordóñez, Martinez, Erick Flores, Martinez, Verónica Anaya, Mussali-Galante, Patricia, Fortoul, Teresa I.
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
antioxidants
Antiparkinson Agents - therapeutic use
Behavioral psychophysiology
Biological and medical sciences
bromocriptine
Bromocriptine - therapeutic use
caudate nucleus
Caudate Nucleus - metabolism
Caudate Nucleus - ultrastructure
Disease Models, Animal
Dopamine - metabolism
Fundamental and applied biological sciences. Psychology
Male
Motor Endplate - metabolism
Motor Endplate - ultrastructure
neuroprotection
oxidative stress
Oxidative Stress - physiology
Parkinson Disease - diagnosis
Parkinson Disease - drug therapy
Parkinson Disease - metabolism
Parkinson's disease
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
ultrastructure
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Summary:The objective of this article was to identify the effects of bromocriptine on the ultrastructure of the caudate nucleus in rats with a 6-hydroxidopamine (6-OHDA) unilateral lesion of the substantia nigra pars compacta. Eighteen Wistar male rats were stereotactically lesioned with 6-OHDA (n = 12), or sham lesioned (n = 6). Two days after rotational behavior was tested, and 2 days later, 6 rats were treated with 0.3 mg/Kg bromocriptine orally for a month and 6 rats were kept for the same time without treatment. The neuropile of the sham operated and bromocriptine-treated rats was well preserved contrary to the non-bromocriptine-treated rats. Also, it was found that there was a significant difference in the number of synaptic endings with edema in caudate of bromocriptine-treated rats compared with non-treated rats; however, the size of the synaptic endings were different to those found in the sham lesioned rats. Also, as in the sham lesioned group, the bromocriptines showed more synaptic contacts with dendritic spines contrasting to the non-treated group. The results suggest that bromocriptine possesses antioxidant properties because it decreased the ultrastructural alterations after 6-OHDA lesion.
ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450590897059