Kadsuphilactones A and B, two new triterpene dilactones from kadsuraphilippinensis

[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and...

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Bibliographic Details
Published in:Organic letters 2005-07, Vol.7 (15), p.3307
Main Authors: Shen, Ya-Ching, Lin, Yu-Chi, Chiang, Michael Y, Yeh, Sheau Farn, Cheng, Yuan-Bin, Liao, Chia-Ching
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Crystallography, X-Ray
Hepatitis B virus - drug effects
Inhibitory Concentration 50
Kadsura - chemistry
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Molecular Structure
Plants, Medicinal - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.
ISSN:1523-7060
1523-7052