Paralytic ileus due to vinorelbine

Intestinal obstruction is very common in cancer patients and occurs in 80% of cases with malignant aetiology. Hence, aggressive treatment is needed in most cases. The occlusion can be caused by luminal obstruction, paralysis of the intestinal muscle or carcinomatosis with mesentery involvement. The...

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Bibliographic Details
Published in:Clinical & translational oncology 2005-05, Vol.7 (4), p.169
Main Authors: Esquerdo Galiana, Gaspar, Briceño García, Hugo, Llorca Ferrándiz, Cristina, Cervera Grau, José Manuel
Format: Article
Language:Spanish
Subjects:
Antineoplastic Agents, Phytogenic - adverse effects
Humans
Intestinal Pseudo-Obstruction - chemically induced
Male
Middle Aged
Vinblastine - adverse effects
Vinblastine - analogs & derivatives
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Summary:Intestinal obstruction is very common in cancer patients and occurs in 80% of cases with malignant aetiology. Hence, aggressive treatment is needed in most cases. The occlusion can be caused by luminal obstruction, paralysis of the intestinal muscle or carcinomatosis with mesentery involvement. The clinical case we present is that of a patient diagnosed as having lung cancer and who was admitted with paralytic ileus following treatment with vinorelbine; a vinca alkaloid whose main characteristic toxicities include neutropenia and peripheral neuropathy. Also, on rare occasions, the drug can cause paralysis of the ileum due to autonomic neuropathy. Hence, before administering aggressive treatment to an occlusive syndrome, cases that could benefit from conservative treatment should be ruled out.
ISSN:1699-048X
1699-3055