Nogo CAA 3'UTR insertion polymorphism is not associated with schizophrenia nor with bipolar disorder

The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. The association of a polymorphism in Nogo was previously investigated by two groups, with divergent results. In this report, using an alternative approach, we evaluated this same polymorphism in...

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Bibliographic Details
Published in:Schizophrenia research 2005-06, Vol.75 (1), p.5-9
Main Authors: GREGORIO, Sheila P, MURY, Fabio B, OJOPI, Elida B, SALLET, Paulo C, MORENO, Doris H, YACUBIAN, Juliana, TAVARES, Hildeberto, SANTOS, Fabricio R, GATTAZ, Wagner F, DIAS-NETO, Emmanuel
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Animals
Biological and medical sciences
Bipolar Disorder - ethnology
Bipolar Disorder - genetics
Bipolar disorders
Brazil - epidemiology
Case-Control Studies
Continental Population Groups - genetics
DNA Transposable Elements
Female
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Haplorhini - genetics
Humans
Male
Medical sciences
Mood disorders
Mutagenesis, Insertional
Myelin Proteins - genetics
Nogo Proteins
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - ethnology
Schizophrenia - genetics
Untranslated Regions
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Summary:The Nogo gene maps to 2p14-p13, a region consistently associated with schizophrenia and bipolar disorder. The association of a polymorphism in Nogo was previously investigated by two groups, with divergent results. In this report, using an alternative approach, we evaluated this same polymorphism in 725 individuals, including patients with schizophrenia, bipolar disorder, normal controls and non-human primate samples. Our results indicate that the polymorphism is not associated with any of these diseases, but has a remarkably biased distribution in ethnic groups. Genotyping of primate samples, suggest that this polymorphism is a recent event in human speciation.
ISSN:0920-9964
1573-2509