Morphological Changes of Follicular Cell Basal Borders and Basement Membranes in Benign and Malignant Nodular Lesions of the Thyroid Gland: An Ultrastructural Study

Microfollicular nodular lesions of the thyroid gland may represent a differential diagnosis problem. Firstly, nodular areas of follicular hyperplasia have to be distinguished from follicular adenomas. On the other hand, nodular microfollicular areas exhibiting large pale nuclei, occasionally found i...

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Bibliographic Details
Published in:Ultrastructural pathology 2004-07, Vol.28 (4), p.199-207
Main Authors: Cavallari, Vittorio, Albiero, Francesca, Cicciarello, Rocco, Gagliardi, Maria Ester, Costa, Gregorio, D'Alia, Claudio, Sturniolo, Giovanni, Tonante, Ada, Labate, Agata, Torre, Valerio, Vermiglio, Francesco, Caillou, Bernard
Format: Article
Language:English
Subjects:
Adenoma - pathology
Adenoma - ultrastructure
Adult
Aged
Basement Membrane - pathology
Basement Membrane - ultrastructure
Diagnosis, Differential
electron microscopy
Female
follicular basal borders
Humans
Hyperplasia - pathology
Male
Microscopy, Electron, Transmission
Middle Aged
Thyroid Nodule - pathology
Thyroid Nodule - ultrastructure
Thyroid tumors
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Summary:Microfollicular nodular lesions of the thyroid gland may represent a differential diagnosis problem. Firstly, nodular areas of follicular hyperplasia have to be distinguished from follicular adenomas. On the other hand, nodular microfollicular areas exhibiting large pale nuclei, occasionally found in hyperplastic nodules and follicular adenomas, must be discriminated from latent papillary carcinomas with predominant follicular architecture. The diagnosis of follicular carcinoma still requires the detection of vascular and/or capsular microinvasion. A more refined study was planned to search for additional descriptors useful for diagnosis The authors report the results of an ultrastructural investigation carried out on 220 thyroid nodular lesions and 50 specimens of macroscopically nonnodular glands. An infolding arrangements of the thyreocyte basal border(TBB) and follicular basement membrane (FBM) was demonstrated in 50/50 nonnodular thyroid tissue specimens and 53/67 (79.1%) hyperplastic nodular lesions (p < .005). A linear arrangement of the TBB and FBM was found in 85/121(70.2%) follicular adenomas and in 32/32 differentiated carcinomas (p < .001). In the last group, 12/32 (37.5%) cases showed focal discontinuities of FBM. In conclusion, the benign thyroid nodules show a prevalently infolding arrangements of TBBs, whereas the majority of proliferative lesions display a linear morphology. In absence of an infiltrating pattern there is no morphological evidence of discriminating potentially malignant vs. benign lesions. The linear distribution of TBBs and FBMs places the case in a group of borderline lesions that involve a more careful postsurgery investigation.
ISSN:0191-3123
1521-0758
DOI:10.1080/019131290505130