Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs

Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting s...

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Bibliographic Details
Published in:Genetics and molecular research 2004, Vol.3 (4), p.465-473
Main Authors: Miziara, M.N, Riggs, P.K, Amaral, M.E.J
Format: Article
Language:English
Subjects:
3' Untranslated Regions - genetics
5' Untranslated Regions - genetics
Animals
Base Sequence
Cattle
comparative genomics
Conserved Sequence - genetics
Evolution, Molecular
genomics
Humans
Mice
Molecular Sequence Data
Sequence Alignment
sequence analysis
Sequence Analysis, DNA - methods
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Summary:Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to identify noncoding conservation patterns of 39 human and bovine orthologous genes. Seventy-three conserved noncoding sequences were identified that shared greater than 70% identity over at least 100 bp. Thirteen of these conserved sequences were also identified in the mouse genome. Evolutionary conservation of noncoding sequences across diverse species may have functional significance, and these conserved sequences may be good candidates for regulatory elements.
ISSN:1676-5680
1676-5680