Combination therapies in spondyloarthropathies

To compare the efficacy and tolerability of single-agent sulfasalazine (SSZ) with combination therapies composed of SSZ and methotrexate (MTX) and SSZ, MTX and hydroxychloroquine (HCQ) in active spondyloarthropathy (SpA) patients with peripheral arthritis. One hundred and fifty SpA patients with per...

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Bibliographic Details
Published in:Kobe journal of the medical sciences 2004, Vol.50 (1-2), p.31
Main Authors: Calgüneri, Meral, Cobankara, Veli, Oztürk, M Akif, Ertenli, Ihsan, Kiraz, Sedat, Apraş, Sule
Format: Article
Language:English
Subjects:
Adult
Arthritis - diagnostic imaging
Arthritis - drug therapy
Drug Therapy, Combination
Female
Humans
Hydroxychloroquine - administration & dosage
Male
Methotrexate - administration & dosage
Radiography
Spondylarthropathies - diagnostic imaging
Spondylarthropathies - drug therapy
Sulfasalazine - administration & dosage
Treatment Outcome
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Summary:To compare the efficacy and tolerability of single-agent sulfasalazine (SSZ) with combination therapies composed of SSZ and methotrexate (MTX) and SSZ, MTX and hydroxychloroquine (HCQ) in active spondyloarthropathy (SpA) patients with peripheral arthritis. One hundred and fifty SpA patients with peripheral arthritis (male/ female: 92/58) who were treated in our clinic between 1994 and 1998 were enrolled in this trial. Patients treated with SSZ alone (1-3 gr/day) were included in Group I, patients treated with combination of SSZ (1-3 gr/day) and MTX (7.5-15 mg/week) in Group II, and patients treated with combination of SSZ (1-3 gr/day), MTX (7.5-15 mg/week) and HCQ (200 mg/day) in Group III. Forty-eight patients in Group I, 45 patients in Group II and III were eligible for statistical analysis at the end of study. The combination of MTX, SSZ, and HCQ, and the combination of MTX and SSZ were more effective regarding the clinical and laboratory parameters than SSZ alone (p
ISSN:0023-2513
1883-0498