P21WAF1/CIP1 Protein and Tongue Cancer Prognosis

The expression of the cell cycle regulatory protein p21 waf1/cip1 was analyzed immunohistochemically in tissue from the tumor and adjacent non-tumor epithelia of 54 patients with tongue cancer in order to determine the proportion of tongue carcinomas with altered p21 waf1/cip1 expression, establish...

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Bibliographic Details
Published in:Anticancer research 2004-09, Vol.24 (5B), p.3225-3231
Main Authors: Gonzalez-Moles, M A, Ruiz-Avila, I, Martinez, J A Fernández, Gil-Montoya, J A, Esteban, F, Gonzalez-Moles, S, Bravo-Perez, M, Bascones, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cyclin-Dependent Kinase Inhibitor p21
Cyclins - biosynthesis
Female
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Prognosis
Survival Rate
Tongue Neoplasms - metabolism
Tongue Neoplasms - pathology
Tumors
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Summary:The expression of the cell cycle regulatory protein p21 waf1/cip1 was analyzed immunohistochemically in tissue from the tumor and adjacent non-tumor epithelia of 54 patients with tongue cancer in order to determine the proportion of tongue carcinomas with altered p21 waf1/cip1 expression, establish whether this alteration is an early event in tongue carcinogenesis and to investigate whether p21 waf1/cip1 expression has predictive prognostic value in these tumors. The percentage of p21 waf1/cip1 -positive neoplastic cells was calculated. Adjacent non-tumor epithelium was classified as normal, hyperplastic or dysplastic, and the p21 waf1/cip1 expression was only considered normal in suprabasal layers. P21 waf1/cip1 expression was negative in 57.4% (31/54) of the tumors and was aberrant in the non-tumor adjacent tissue of all patients studied. Neither the absence nor the degree of p21 waf1/cip1 expression influenced the survival of patients in the present series. P21 waf1/cip1 system alteration may be an early and frequent event in tongue carcinogenesis.
ISSN:0250-7005
1791-7530