B-cell Chronic Lymphocytic Leukemia with Aberrant CD8 Expression: Genetic and Immunophenotypic Analysis of Prognostic Factors

B-cell chronic lymphocytic leukemia (B-CLL) is phenotypically characterized by cell surface co-expression of CD19, CD20, CD5, and CD23. However, the concomitant presence of other antigens distinctive of a particular leukocyte subset, e.g. T cells, is an unusual finding in B-CLL. In the present repor...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia & lymphoma 2004-08, Vol.45 (8), p.1677-1681
Main Authors: Schroers, Roland, Pukrop, Tobias, Dürig, Jan, Haase, Detlef, Dührsen, Ulrich, Trümper, Lorenz, Griesinger, Frank
Format: Article
Language:English
Subjects:
Aged
B-cell chronic lymphocytic leukemia (B-CLL)
Biomarkers, Tumor - metabolism
CD38 antigen
CD8 antigen
CD8 Antigens - metabolism
Chromosome Aberrations
Flow Cytometry
Humans
Immunoglobulin Heavy Chains - genetics
Immunoglobulin heavy-chain variable-region (IgVH) gene mutational status
Immunoglobulin Variable Region - genetics
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Male
Prognosis
Prognostic marker
Protein tyrosine kinase ZAP-70
Protein-Tyrosine Kinases - analysis
Protein-Tyrosine Kinases - genetics
ZAP-70 Protein-Tyrosine Kinase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:B-cell chronic lymphocytic leukemia (B-CLL) is phenotypically characterized by cell surface co-expression of CD19, CD20, CD5, and CD23. However, the concomitant presence of other antigens distinctive of a particular leukocyte subset, e.g. T cells, is an unusual finding in B-CLL. In the present report, a case of B-CLL with aberrant expression of the T-cell-associated antigen CD8 is described. Flow cytometric analysis of the patient's cells demonstrated lack of CD38 expression, and cytogenetic analysis by FISH did not show any abnormalities of chromosomes 17p, 11q, and 12. Furthermore, the B-CLL cells expressed only low levels of the tyrosine kinase ZAP-70, which was in agreement with the mutated status of the immunoglobulin heavy-chain variable-region gene (IgVH). In summary, the determined profile of prognostic markers together with the highly stable and indolent disease in the described patient suggest a good prognosis of B-CLL with aberrant CD8 expression.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190410001683697