p53 designer genes for the modern mouse

Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences that present the precise human DNA-binding domain as mutation target could be informative models to test p53 rescue drugs, and to explore exp...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2004-06, Vol.3 (6), p.738
Main Authors: Hergenhahn, Manfred, Luo, Jun-Li, Hollstein, Monica
Format: Article
Language:English
Subjects:
Animals
Genes, p53 - genetics
Genetic Engineering
Genetic Enhancement
Humans
Mice
Online Access:Get full text
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Summary:Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences that present the precise human DNA-binding domain as mutation target could be informative models to test p53 rescue drugs, and to explore experimentally the causes of human tumor mutations.
ISSN:1551-4005