Lack of HIN-1 Methylation Defines Specific Breast Tumor Subtypes Including Medullary Carcinoma of the Breast and BRCA1-Linked Tumors

Medullary carcinoma is a poorly differentiated breast cancer with a high histologic grade and a paradoxically good prognosis. It accounts for only 3% of all breast cancers except in BRCA-1 families, in which it can account for as many as 13% of cancers. To date, only histologic criteria have been us...

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Bibliographic Details
Published in:Cancer biology & therapy 2003-09, Vol.2 (5), p.559-563
Main Authors: Tisserand, Pascaline, Fouquet, Coralie, Barrois, Michel, Gallou, Catherine, Dendale, Rémi, Stoppa-Lyonnet, Dominique, Sastre-Garau, Xavier, Fourquet, Alain, Soussi, Thierry
Format: Article
Language:English
Subjects:
Binding
Biology
Bioscience
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Calcium
Cancer
Carcinoma, Ductal - genetics
Carcinoma, Ductal - pathology
Carcinoma, Medullary - genetics
Carcinoma, Medullary - pathology
Cell
Cycle
Cytokines - genetics
DNA Methylation
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
Female
Genes, BRCA1 - physiology
Genes, p53 - physiology
Genetic Predisposition to Disease
Humans
Landes
Mutation - genetics
Organogenesis
Promoter Regions, Genetic
Proteins
RNA, Neoplasm - genetics
RNA, Neoplasm - metabolism
Tumor Suppressor Proteins - genetics
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Summary:Medullary carcinoma is a poorly differentiated breast cancer with a high histologic grade and a paradoxically good prognosis. It accounts for only 3% of all breast cancers except in BRCA-1 families, in which it can account for as many as 13% of cancers. To date, only histologic criteria have been used to define this tumor type. In an attempt to more clearly define the genetic pathway leading to this subtype of cancer, we recently demonstrated that nearly 100% of these carcinomas display p53 mutations. In the present study, we extended our analysis to include HIN-1, a candidate tumor suppressor that has been shown to be silenced by methylation in the majority of breast tumors. In striking contrast to unselected sporadic invasive ductal carcinoma, we show that medullary carcinomas do not display a high frequency of HIN-1 methylation (p
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.2.5.511