The evolving role of platelets in inflammation

Platelets are small in size and simple in structure. Nevertheless, these anucleate cytoplasts utilize complex molecular systems to regulate a variety of biological functions. Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that int...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2003-09, Vol.1 (9), p.1897-1905
Main Authors: Weyrich, A. S., Lindemann, S., Zimmerman, G. A.
Format: Article
Language:English
Subjects:
Blood Platelets - metabolism
Blood Platelets - physiology
Humans
inflammation
Inflammation - blood
Inflammation - etiology
Integrins - physiology
Phylogeny
Platelet Activation
platelets
Thrombosis - blood
Thrombosis - etiology
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Summary:Platelets are small in size and simple in structure. Nevertheless, these anucleate cytoplasts utilize complex molecular systems to regulate a variety of biological functions. Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases.
ISSN:1538-7933
1538-7836
DOI:10.1046/j.1538-7836.2003.00304.x