Expression of markers of immunocompetent cells, cytokine level, and L-arginine metabolism in complex extremely high frequency and interferon therapy of inflammatory diseases in women of highlands

Chronic inflammatory gynecological diseases (CIGD) in highlanders (2,100-2,200 m a.s.l.) are accompanied with the following changes in immunoregulatory parameters: strengthening in the expression of CD3+ (TCR), CD4+ (T-helpers), CD16+ (NK-cells), CD25+ (activated IL-2R), increase in CD4+/CD8+ ratio,...

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Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2003, Vol.49 (3), p.80
Main Authors: Taradiĭ, N N, Bagdasarova, I V, Uzdenova, Z Kh, Bichekueva, F Kh, Doloman, L B, Kotsiuruba, A V, Krivokhatskaia, L D, Kamenetskaia, O V, Mandziuk, Ia P, Volkova, L N
Format: Article
Language:Russian
Subjects:
Adult
Altitude
Antigens, CD - blood
Arginine - metabolism
Biomarkers - blood
Combined Modality Therapy
Cytokinins - blood
Female
Humans
Hypoxia - metabolism
Interferon Type I - therapeutic use
Interferon-alpha
Killer Cells, Natural - metabolism
Microwaves - therapeutic use
Middle Aged
Pelvic Inflammatory Disease - immunology
Pelvic Inflammatory Disease - metabolism
Pelvic Inflammatory Disease - therapy
Receptors, Antigen - biosynthesis
Recombinant Proteins
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:Chronic inflammatory gynecological diseases (CIGD) in highlanders (2,100-2,200 m a.s.l.) are accompanied with the following changes in immunoregulatory parameters: strengthening in the expression of CD3+ (TCR), CD4+ (T-helpers), CD16+ (NK-cells), CD25+ (activated IL-2R), increase in CD4+/CD8+ ratio, levels of circulating cytokines--alpha-, beta-, gamma-interferon (IFN) and alpha-, beta-tumor necrotizing factor (TNF), strengthening in immune adhesion of thrombocytes (IAT), and inhibition of the oxidative metabolic way of L-arginine with redistribution of the main metabolites formed via its non-oxidative way. Complex extremely high frequency (EHF) therapy and interferon (with Laferon) therapy of CIGD normalized expression of the differentiated and functional CD-markers of immunocompetent cells (ICC), CD4+/CD8+ ratio, increased expression of CD8+, decreased IAT and levels of circulating cytokines (IFN, TNF), changed L-arginine metabolism with activation of the oxidative way. Full-value of the population signs of immune stabilization due to the treatment was complemented with increase in the ICC functional parameters--markers of mitochondrial, lysosomal and mitotic activity. We first demonstrated a high effectiveness of complex use of EHF and Laferon as an immunocorrective therapy of CIGD in highlanders.
ISSN:2522-9028