Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium

Escherichia coli O157:H7 and Salmonella are widely recognized as important agents of food-borne disease with worldwide distribution. The use of ionophores in feeding growing ruminants is widespread in the United States and has attracted recent interest due to the apparent temporal relationship betwe...

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Bibliographic Details
Published in:Journal of animal science 2003-02, Vol.81 (2), p.553-560
Main Authors: Edrington, T.S, Callaway, T.R, Bischoff, K.M, Genovese, K.J, Elder, R.O, Anderson, R.C, Nisbet, D.J
Format: Article
Language:English
Subjects:
animal growth
Animal productions
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
antibacterial properties
bacterial contamination
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
bambermycin
Bambermycins - administration & dosage
Bambermycins - pharmacology
Biological and medical sciences
Carrier State - microbiology
Carrier State - veterinary
Colony Count, Microbial - veterinary
Diarrhea - microbiology
Diarrhea - veterinary
Drug Resistance, Bacterial
Escherichia coli Infections - microbiology
Escherichia coli Infections - veterinary
Escherichia coli O157 - drug effects
Escherichia coli O157 - growth & development
Escherichia coli O157:H7
feces
Feces - microbiology
feed additives
Female
Food industries
Food Microbiology
food pathogens
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Infectious diseases
ionophores
Ionophores - administration & dosage
Ionophores - pharmacology
lamb feeding
lambs
Male
Meat and meat product industries
Medical sciences
monensin
Monensin - administration & dosage
Monensin - analogs & derivatives
Monensin - pharmacology
on-farm food safety
propionates
Random Allocation
Salmonella Infections, Animal - microbiology
Salmonella typhimurium
Salmonella typhimurium - drug effects
Salmonella typhimurium - growth & development
shedding
Sheep
Sheep Diseases - microbiology
Terrestrial animal productions
Vertebrates
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Summary:Escherichia coli O157:H7 and Salmonella are widely recognized as important agents of food-borne disease with worldwide distribution. The use of ionophores in feeding growing ruminants is widespread in the United States and has attracted recent interest due to the apparent temporal relationship between initial ionophore use and the increase in human E. coli O157:H7 cases. Two experiments were conducted to evaluate the effects of short-term feeding of ionophores on fecal shedding, intestinal concentrations, and antimicrobial susceptibility of E. coli O157:H7 and S. typhimurium in growing lambs. Sixteen lambs were used in each experiment, four lambs per treatment group: monensin, laidlomycin propionate, bambermycin, and a control treatment. Lambs were fed a grain and hay (50:50) diet with their respective ionophore for 12 d before experimental inoculation with E. coli O157:H7 or S. typhimurium. Animals were maintained on their respective diets an additional 12 d, and fecal shedding of inoculated pathogens was monitored daily. Lambs were killed and tissues and contents were sampled from the rumen, cecum, and rectum. No differences (P > 0.05) in fecal shedding of Salmonella or E. coli O157:H7 were observed due to treatment. Occurrence of Salmonella or E. coli in luminal contents and tissue samples from the rumen, cecum, and rectum did not differ (P > 0.05) among treatments. Feeding monensin decreased (P < 0.05) the incidence of scours in sheep infected with Salmonella compared with the other treatments. No differences in antimicrobial susceptibility were found in any of Salmonella or E. coli O157:H7 isolates. Results from these studies indicate that short-term ionophore feeding had very limited effects on E. coli and Salmonella shedding or on antimicrobial susceptibility in experimentally infected lambs.
ISSN:1525-3163
0021-8812
1525-3163
DOI:10.2527/2003.812553x