Inhibition of NOS enhances pulmonary vascular changes in stroke-prone spontaneously hypertensive rats

Departments of Pediatrics, Pharmacology, and Pathology, New York Medical College, Valhalla, New York 10595 To determine the effects of chronic nitric oxide (NO) blockade on the pulmonary vasculature, 58-day-old spontaneously hypertensive rats of the stroke-prone substrain (SHRSP) and Wistar-Kyoto ra...

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Published in:American journal of physiology. Lung cellular and molecular physiology 2000-01, Vol.278 (1), p.81-L89
Main Authors: Mathew, Rajamma, Fan, Newton Y.-T, Yuan, Ning, Chander, Praveen N, Gewitz, Michael H, Stier, Charles T., Jr
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Blood Vessels - drug effects
Blood Vessels - physiopathology
Cyclic AMP - physiology
Cyclic GMP - physiology
Endothelium, Vascular - physiopathology
Enzyme Inhibitors - pharmacology
Genetic Predisposition to Disease
Hypertension, Pulmonary - genetics
Hypertension, Pulmonary - pathology
Hypertension, Pulmonary - physiopathology
Hypertrophy, Left Ventricular - pathology
Hypertrophy, Right Ventricular - pathology
Lung - pathology
Nitric Oxide Synthase - antagonists & inhibitors
Nitroarginine - pharmacology
Pulmonary Circulation - drug effects
Rats
Rats, Inbred SHR - genetics
Rats, Inbred WKY
Stroke - genetics
Vasodilation
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Summary:Departments of Pediatrics, Pharmacology, and Pathology, New York Medical College, Valhalla, New York 10595 To determine the effects of chronic nitric oxide (NO) blockade on the pulmonary vasculature, 58-day-old spontaneously hypertensive rats of the stroke-prone substrain (SHRSP) and Wistar-Kyoto rats (WKY) received N -nitro- L -arginine ( L -NNA; 15 mg · kg 1 · day 1 orally for 8 days). Relaxation to acetylcholine (ACh) in hilar pulmonary arteries (PAs), the ratio of right ventricular (RV) to body weight (RV/BW) to assess RV hypertrophy (RVH), and the percent medial wall thickness (WT) of resistance PAs were examined. L -NNA did not alter the PA relaxation, RV/BW, or WT in WKY. Although the PA relaxation and RV/BW in control SHRSP were comparable to those in WKY, the WT was increased (31 ± 2 vs. 19 ± 1%). L -NNA-treated SHRSP showed two patterns: in one group, the relaxation, RV/BW, and WT were comparable to those in the control SHRSP; in the other, impaired relaxation (36 ± 7 vs. 88 ± 4% for WKY) was associated with an increase in WT (37 ± 1%) and RV/BW (0.76 ± 0.05). Thus the abnormal pulmonary vasculature in SHRSP at
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.2000.278.1.L81