Estrogen Inhibits the Vascular Injury Response in Estrogen Receptor β -Deficient Female Mice

The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERα and ERβ . We demonstrated previously that estrogen inhibits the response to vascular injury in both...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-12, Vol.96 (26), p.15133-15136
Main Authors: Karas, Richard H., Hodgin, Jeffrey B., Kwoun, Moon, Krege, John H., Aronovitz, Mark, Mackey, William, Gustafsson, Jan Ake, Korach, Kenneth S., Smithies, Oliver, Mendelsohn, Michael E.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Blood vessels
Cardiovascular system
Carotid Artery Injuries - drug therapy
Cell Division - drug effects
ERa protein
ERb protein
Estradiol - therapeutic use
Estrogen Receptor beta
Estrogen receptors
Estrogens
Female
Female animals
Injuries
Medical research
Medicin och hälsovetenskap
Messenger RNA
Mice
Mice, Knockout
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - drug effects
Ovariectomy
Physical trauma
Polymerase chain reaction
Protective effects
Receptors, Estrogen - genetics
Rodents
Vascular system injuries
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Summary:The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERα and ERβ . We demonstrated previously that estrogen inhibits the response to vascular injury in both wild-type and ERα -deficient mice, and that ERβ is expressed in the blood vessels of each, suggesting a role for ERβ in the vascular protective effects of estrogen. In the present study, we examined the effect of estrogen administration on mouse carotid arterial injury in ERβ -deficient mice. Surprisingly, in ovariectomized female wild-type and ERβ knockout mice, 17β -estradiol markedly and equally inhibited the increase in vascular medial area and the proliferation of vascular smooth muscle cells after vascular injury. These data demonstrate that ERβ is not required for estrogen-mediated inhibition of the response to vascular injury, and suggest that either of the two known estrogen receptors is sufficient to protect against vascular injury, or that another unidentified estrogen receptor mediates the vascular protective effects of estrogen.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.26.15133