Temperature conditioning of nasal air: effects of vasoactive agents and involvement of nitric oxide

1  Medical Service, Portland Veterans Affairs Medical Center, and 2  Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon 97201 Nitric oxide (NO) is released into nasal air, but its function is unknown. We hypothesized that nasal vascular tone and/or flow influences temp...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1999-10, Vol.87 (4), p.1260-1265
Main Authors: Holden, William E, Wilkins, John P, Harris, Michelle, Milczuk, Henry A, Giraud, George D
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Adult
Air
Air breathing
Anatomy & physiology
Biological and medical sciences
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Nasal Cavity - drug effects
Nasal Cavity - metabolism
Nasal Cavity - physiology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - metabolism
Nitric Oxide - physiology
Nose
Oxymetazoline - pharmacology
Papaverine - pharmacology
Reference Values
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Temperature
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
Vertebrates: respiratory system
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Summary:1  Medical Service, Portland Veterans Affairs Medical Center, and 2  Department of Otolaryngology, Oregon Health Sciences University, Portland, Oregon 97201 Nitric oxide (NO) is released into nasal air, but its function is unknown. We hypothesized that nasal vascular tone and/or flow influences temperature conditioning of nasal air and that NO participates in this process. We measured nasal air temperature (via a thermocouple) and exhaled nasal NO release (by chemiluminescence) in five humans and examined the effects of an aerosolized vasoconstrictor (oxymetazoline), a vasodilator (papaverine), N G -nitro- L -arginine methyl ester, an inhibitor of NO synthase, or saline (control). Compared with saline (which caused no changes in nasal air temperature or exhaled NO release), oxymetazoline (0.05%) reduced nasal air temperature and NO release (130.8 ±   15.1 to 81.3 ± 12.8 nl · min 1 · m 2 ; P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1999.87.4.1260