Alkylboronic Esters from Copper-Catalyzed Borylation of Primary and Secondary Alkyl Halides and Pseudohalides

Easy access: An unprecedented copper‐catalyzed cross‐coupling reaction of the title compounds with diboron reagents is described (see scheme; Ts=4‐toluenesulfonyl). This reaction can be used to prepare both primary and secondary alkylboronic esters having diverse structures and functional groups. Th...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2012-01, Vol.51 (2), p.528-532
Main Authors: Yang, Chu-Ting, Zhang, Zhen-Qi, Tajuddin, Hazmi, Wu, Chen-Cheng, Liang, Jun, Liu, Jing-Hui, Fu, Yao, Czyzewska, Maria, Steel, Patrick G., Marder, Todd B., Liu, Lei
Format: Article
Language:English
Subjects:
alkanes
Alkylation
Boron Compounds - chemical synthesis
Boron Compounds - chemistry
boronates
Catalysis
copper
Copper - chemistry
cross-coupling
Esters - chemical synthesis
Esters - chemistry
synthetic methods
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Summary:Easy access: An unprecedented copper‐catalyzed cross‐coupling reaction of the title compounds with diboron reagents is described (see scheme; Ts=4‐toluenesulfonyl). This reaction can be used to prepare both primary and secondary alkylboronic esters having diverse structures and functional groups. The resulting products would be difficult to access by other means.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106299