Gastric Emptying is Delayed in Transgastric Notes: A Randomized Study in Swine

Aim The aim of this study was to evaluate the restoration of gastrointestinal motility after NOTES using capsule endoscopy (CE). Materials and Methods Twenty adult Yorkshire pigs were randomly assigned to four groups: transgastric NOTES (gNOTES), transrectal NOTES (rNOTES), transvaginal NOTES (vNOTE...

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Published in:The Journal of surgical research 2012-05, Vol.174 (2), p.e61-e67
Main Authors: Córdova, Henry, M.D, Guarner-Argente, Carlos, M.D, Martínez-Pallí, Graciela, Ph.D, Navarro, Ricard, M.D, Rodríguez-D'Jesús, Antonio, M.D, Rodríguez de Miguel, Cristina, Beltrán, Mireia, Martínez-Zamora, M. Àngels, M.D, Comas, Jaume, M.D, Lacy, Antonio M., Ph.D, Thompson, Christopher C., M.D., M.H.E.S, Fernández-Esparrach, Gloria, M.D., Ph.D
Format: Article
Language:English
Subjects:
Animals
Capsule Endoscopy
Female
Gastric Emptying
gastrointestinal motility
Laparoscopy
Natural Orifice Endoscopic Surgery - adverse effects
peritoneoscopy
Random Allocation
Stomach - surgery
Surgery
Swine
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Summary:Aim The aim of this study was to evaluate the restoration of gastrointestinal motility after NOTES using capsule endoscopy (CE). Materials and Methods Twenty adult Yorkshire pigs were randomly assigned to four groups: transgastric NOTES (gNOTES), transrectal NOTES (rNOTES), transvaginal NOTES (vNOTES), and laparoscopy (LAP). At the end of a 30-min peritoneoscopy with identification of seven predetermined organs, an array of eight receivers and the recorder were attached to the abdominal wall. The CE was delivered into the antrum with the help of an endoscope and a polypectomy snare. Animals were kept alive for 14 d. Results Median time for surgery was longer in gNOTES (56 min, range 47–63) and vNOTES (54 min, range 44–79) than in LAP (32 min, range 32–33; P < 0.05 and P < 0.01) and in rNOTES (45.5 min, range 33–56) ( P = ns). This increase was related to a larger incision and longer closure times. Images from the CE were successfully retrieved in 19 cases. The CE was retained in the stomach in all animals in gNOTES (459 min; range 360–600), but only in one animal in rNOTES and vNOTES and in none in the LAP group. Failure of passage of the CE beyond the stomach was associated with gNOTES and longer closure of the incision. Animals in the gNOTES group gained less weight than the others and this change was statistical significant when compared with vNOTES animals (1.7 kg, range –1.98 to 4.5 versus 8.4 kg, range 5.8 to 11.45; P < 0.01). Conclusion Gastric emptying is delayed after gNOTES peritoneoscopy compared with rNOTES, vNOTES, and LAP and this effect is associated with less weight gain.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2011.10.034