Biological Activity of Some Derivatives of β-Cyclodextrin

New compounds of β-cyclodextrin containing covalently bound (conjugated) residues of acetylsalicylic and 1-(4-isobutylphenyl)-propionic acids were synthesized in the reaction of chlorides of the corresponding acids with β-cyclodextrin. We studied antiplatelet and antiphlogistic properties of these s...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-10, Vol.151 (6), p.698-701
Main Authors: Batalova, T. A., Dorovskich, V. A., Kurochkina, G. I., Grachev, M. K., Plastinin, M. L., Sergievich, A. A.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Aspirin - chemistry
beta-Cyclodextrins - chemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Clathrate compounds
Cyclodextrins
Edema - drug therapy
Ibuprofen
Ibuprofen - therapeutic use
Internal Medicine
Laboratory Medicine
Mice
Molecular Structure
Pathology
Platelet Aggregation - drug effects
Propionates - chemistry
Structure-Activity Relationship
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Summary:New compounds of β-cyclodextrin containing covalently bound (conjugated) residues of acetylsalicylic and 1-(4-isobutylphenyl)-propionic acids were synthesized in the reaction of chlorides of the corresponding acids with β-cyclodextrin. We studied antiplatelet and antiphlogistic properties of these substances. It was shown that new compounds are comparable and in some cases are superior to the reference drugs acetylsalicylic acid and ibuprofen by anti-inflammatory and antiaggregant activities.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1419-4