Predictors of the Development of Surgical Complications among Hematopoietic Stem Cell Transplantation Recipients

Background This study was designed to determine possible risk factors for the development of surgical complications after hematopoietic stem cell transplantation (HSCT). HSCT carries the possibility for the development of surgical morbidities and mortalities; certain populations of patients are at h...

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Bibliographic Details
Published in:World journal of surgery 2012-05, Vol.36 (5), p.1003-1010
Main Authors: Anabtawi, Iyad, Abdelrahman, Fawzi, Alomari, Ahamd, Ba’ba’, Murad, Al Masri, Mahmoud
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adolescent
Adult
Bone Marrow Transplantation
Cardiac Surgery
Child
Child, Preschool
Conditioning Regimen
Cord Blood Stem Cell Transplantation
Female
Follow-Up Studies
General Surgery
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation Recipient
Hemorrhagic Cystitis
Humans
Infant
Male
Medicine
Medicine & Public Health
Peripheral Blood Stem Cell Transplantation
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Retrospective Studies
Risk Factors
Surgery
Thoracic Surgery
Total Body Irradiation
Transplantation Conditioning - adverse effects
Transplantation Conditioning - methods
Vascular Surgery
Whole-Body Irradiation
Young Adult
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Summary:Background This study was designed to determine possible risk factors for the development of surgical complications after hematopoietic stem cell transplantation (HSCT). HSCT carries the possibility for the development of surgical morbidities and mortalities; certain populations of patients are at higher risk for developing complications. Defining those risk factors will help surgeons to anticipate and manage these complications. Methods The records of 165 patients at King Hussein Cancer Center (KHCC) were reviewed from January 2007 to December 2008. Patients’ characteristics, including age, source and type of transplant, behavior of disease, total body irradiation (TBI), immunity status, and intensity of conditioning were studied. Results According to our data, abdominal complications were more common among patients who received TBI versus patients who did not, and in patients who received peripheral blood versus bone marrow and cord blood as the source of stem cells. Ear, nose, and throat (ENT) complications were found more in patients who underwent nonmyeloablation conditioning. Catheter-related complications were found more significantly in immune-compromised patients during the post-engraftment period. We also found that ENT complications were more frequent in patients with cord blood as the source of stem cells, although the results are inconclusive due to the small sample size. Conclusions Pretransplantation factors can be used as predictors for the development of surgical complications in HSCT recipients. Abdominal complications were significantly more common in patients who received total body irradiation as part of their conditioning regimen and when the peripheral blood was a source for stem cell transplantation.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-012-1517-0