Rho proteins crosstalk via RhoGDIalpha: At random or hierarchically ordered?

The small GTPases of the Rho family are key signaling molecules regulating a plethora of biological pathways. They can exert diverse, sometimes opposite, contributions to specific cellular processes explaining why their regulation and their crosstalk must be finely tuned. Several mechanisms driving...

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Bibliographic Details
Published in:Communicative & integrative biology 2012-01, Vol.5 (1), p.99-101
Main Authors: Stultiens, Audrey, Ho, T. T. Giang, Nusgens, Betty V., Colige, Alain C., Deroanne, Christophe F.
Format: Article
Language:English
Subjects:
Addendum
Binding
Biology
Bioscience
Calcium
Cancer
Cell
crosstalk
Cycle
Landes
Organogenesis
Proteins
Rac1
RhoA
RhoC
RhoGDI
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Summary:The small GTPases of the Rho family are key signaling molecules regulating a plethora of biological pathways. They can exert diverse, sometimes opposite, contributions to specific cellular processes explaining why their regulation and their crosstalk must be finely tuned. Several mechanisms driving crosstalk between Rho GTPases have been described in the literature. They implicate proteins regulating their activity or common downstream effectors. Among the proteins regulating Rho GTPases cycling, RhoGDIs were viewed until very recently as passive inhibitors. Here, we will focus on recent data supporting a role for RhoGDIalpha in the crosstalk between RhoGTPases and present our results suggesting that "preferential" RhoGDIalpha-mediated crosstalk takes place between closely related Rho GTPases.
ISSN:1942-0889
1942-0889
DOI:10.4161/cib.18553