Cyclodextrin-based nanogels for pharmaceutical and biomedical applications

Hydrophilic nanogels combine the advantages of hydrogels with certain advantages that are inherent in their nanoscale size. Similar to macrogels, nanogels can contain and protect drugs and regulate their release by incorporating high-affinity functional groups, stimuli-responsive conformations and b...

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Bibliographic Details
Published in:International journal of pharmaceutics 2012-05, Vol.428 (1-2), p.152-163
Main Authors: Moya-Ortega, Maria D., Alvarez-Lorenzo, Carmen, Concheiro, Angel, Loftsson, Thorsteinn
Format: Article
Language:English
Subjects:
biodegradability
Chemistry, Pharmaceutical - methods
Crosslinking
Cyclodextrins
Cyclodextrins - administration & dosage
Cyclodextrins - chemistry
Drug Delivery Systems - methods
drugs
hydrocolloids
Hydrogels - administration & dosage
Hydrogels - chemistry
hydrophilicity
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Nanogels
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - chemistry
Polyethyleneimine - administration & dosage
Polyethyleneimine - chemistry
Polymerization
polymers
surface area
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Summary:Hydrophilic nanogels combine the advantages of hydrogels with certain advantages that are inherent in their nanoscale size. Similar to macrogels, nanogels can contain and protect drugs and regulate their release by incorporating high-affinity functional groups, stimuli-responsive conformations and biodegradable bonds into the polymer network. Similar to nanoparticles, nanogels can easily be administered in liquid form for parenteral drug delivery. The nanoscale size of nanogels gives them a high specific surface area that is available for further bioconjugation of active targeting agents. Biodistribution and drug release can be modulated through size adjustments. The incorporation of hydrophilic cyclodextrin (CD) moieties into the polymeric network of the nanogels provides them with a drug loading and release mechanism that is based on the formation of inclusion complexes without decreasing the hydrophilicity of the network. The covalent attachment of CD molecules to the chemically crosslinked networks may enable the CDs to display fully their ability to form complexes, while simultaneously preventing drug release upon media dilution. The preparation, characterization and advantages for pharmaceutical and biomedical applications of CD-based nanogels are reviewed in this article.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.02.038