Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases

Adam J, Couturier J, Molinié V, Vieillefond A & Sibony M
(2011) Histopathology58, 1064–1071
Clear‐cell papillary renal cell carcinoma: 24 cases of a distinct low‐grade renal tumour and a comparative genomic hybridization array study of seven cases Aims:  To report clinicopathological and genomic...

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Bibliographic Details
Published in:Histopathology 2011-06, Vol.58 (7), p.1064-1071
Main Authors: Adam, Julien, Couturier, Jérôme, Molinié, Vincent, Vieillefond, Annick, Sibony, Mathilde
Format: Article
Language:English
Subjects:
Adult
Age
Aged
array-CGH
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Chromosome Aberrations
Chromosome translocations
Clear cells
clear-cell papillary renal cell carcinoma
Comparative Genomic Hybridization - methods
Cytokeratin
Data processing
DNA, Neoplasm - genetics
Female
genomics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Keratin-7 - metabolism
Kidney
Kidney diseases
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidneys
Male
Malignancy
Medical sciences
Middle Aged
Nephrectomy
Nephrology. Urinary tract diseases
Nuclei
Oligonucleotide Array Sequence Analysis
Papillae
papillary renal cell carcinoma
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
renal tumour
Tubules
Tumors of the urinary system
Vimentin
Vimentin - metabolism
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Summary:Adam J, Couturier J, Molinié V, Vieillefond A & Sibony M
(2011) Histopathology58, 1064–1071
Clear‐cell papillary renal cell carcinoma: 24 cases of a distinct low‐grade renal tumour and a comparative genomic hybridization array study of seven cases Aims:  To report clinicopathological and genomic characteristics of (ccpRCC), a rare, recently characterized renal tumour entity. Methods and results:  Twenty‐four renal tumours identified as ccpRCC were collected. Data from comparative genomic hybridization on microarrays (array‐CGH) were obtained for seven of these. Most tumours (58%) occurred in the absence of renal disease. Mean patient age was 58.1 years. Tumours were small (mean size: 2.4 cm) and classified as pT1. Histological characteristics consisted of tubules and papillae lined by a single layer of small clear cells harbouring low‐grade nuclei (Fuhrman grades 1 or 2). Architectural variations, with compact areas (41% of cases) and a micro‐ or macrocystic pattern (67% of cases) were observed frequently. Immunostaining demonstrated diffuse, strong expression of cytokeratin 7 and vimentin, whereas CD10, racemase, RCC antigen, translocation factor E3, TFE3 and translocation factor EB were consistently negative. In seven tumours, array‐CGH detected no chromosomal imbalances. Conclusions:  Clear‐cell papillary renal cell carcinoma (ccpRCC) were differentiated from other renal neoplasms by a specific constellation of histopathological and immunohistochemical features, without characteristic genomic imbalances. Clinical, histopathological and genomic data suggested that these tumours have a low potential for malignancy.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2011.03857.x