Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

.  Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus Univers...

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Published in:Journal of internal medicine 2012-03, Vol.271 (3), p.294-304
Main Authors: Handberg, A., Højlund, K., Gastaldelli, A., Flyvbjerg, A., Dekker, J. M., Petrie, J., Piatti, P., Beck-Nielsen, H.
Format: Article
Language:English
Subjects:
Adult
Algorithms
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Body Mass Index
Cardiology. Vascular system
CD36 Antigens - blood
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus - blood
Enzyme-Linked Immunosorbent Assay
Europe
Fatty Liver - blood
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Insulin Resistance - physiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
low-grade inflammation
Male
Medical sciences
metabolic syndrome
Middle Aged
nonalcoholic fatty liver disease
Other diseases. Semiology
Predictive Value of Tests
Prospective Studies
sCD36
type 2 diabetes
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Summary:.  Handberg A, Højlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck‐Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus University Hospital, Aarhus, Denmark; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; BHF Glasgow Cardiovascular Research Centre, Glasgow, UK; and San Raffaele Institute, Milan, Italy). Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. J Intern Med 2012; 271: 294–304. Objectives.  Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects. Methods.  In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic–hyperinsulinaemic clamp, carotid atherosclerosis as intima–media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%). Results.  IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2–Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log‐normal distribution (log‐normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P 
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2011.02442.x